Originally coming from America, Black Friday is the day after Thanks giving which sees an impulsive sale across stores in preparation for Christmas. Consumers purchase what they need at exceptionally low prices for just one day only.Black Friday is set to take place on Friday the 29th of November, which means a day of sales across the UK taking place for one day only.
Offering up to 50% off of selected items, stores across the UK including London will draw people in there millions to devour bargains, whether it be fore themselves or somebody else.
The earliest evidence of the phrase Black Friday applied to the day after Thanksgiving in a shopping context suggests that the term originated in Philadelphia, where it was used to describe the heavy and disruptive pedestrian and vehicle traffic that would occur on the day after Thanksgiving. This usage dates to at least 1961. More than twenty years later, as the phrase became more widespread, a popular explanation became that this day represented the point in the year when retailers begin to turn a profit, thus going from being “in the red” to being “in the black”.
In every human has 23 pairs of chromosomes that control the genetic characteristics and body characteristics (Autosome), 22 pairs and control sexual characteristics (Sex Chromosome), 1 pair.
Chromosomal abnormalities can be divided into 2 groups namely the number of chromosomes (Numerical) and the structure of the chromosome (Structural) causing physical or brain disorders.
Chromosome abnormalities can be analyzed by using the PGT-A method (Preimplantation Genetic Testing for Aneuploidy) which is known as PGS (Preimplantation Genetic Screening). PGT-A is a genome sequence or DNA SCREENING provides high detailed of chromosome analysis and can detect both chromosome 24 chromosomes with high accuracy (99.9%).
At Siam Fertility Clinic, PGT-A is provided by NGS or Next Generation Sequencing technology analyzes genetic diseases due to chromosomal abnormalities before embryo implantation to increase the chances of pregnancy that is completely normal and can reduce miscarriage rates.
Who can benefit from PGT-A?
- Female whose age over 35 years (Advanced Maternal Age; AMA) has a risk of giving birth to children with Down’s syndrome.
- Male / female patients who has a history of genetic disorders in the family.
- People with history of unsuccessful fertility treatments, or having many times of recurrent miscarriage
Gene is considered a genetic basis appears on the chromosome, consisting of DNA which determines the genetic characteristics of the organism.
In humans, there are many different genes in size from small genes with only a few DNA to genes with more than two million of DNA. Currently, there are estimation that all genes in humans are about 20,000 to 25,000 genes.
In everyone, there are 2 copies of gen, divided from the father and another one copy from the mother. If there is a change in any copy or both copies whether missing the gene or changing in order of DNA within the gene may cause changes when transmitted to the next generation, there are some characteristics that are different from the original. The diseases caused by abnormalities at the gene level can be divided into 2 groups: (1) Single Gene Disorder which abnormalities may be caused by genetic inheritance of Dominant genes in both body chromosome and sex chromosome (X-linked) and Recessive genes, such as thalassemia, and polycystic kidney disease. (2) Genetic mutation which is a disease cause by factors of living or changing environment (Multiple Gene/Muttifactorial Disorder) such as heart disease, Alzheimer’s disease, diabetes, cancer and obesity.
At Siam Fertility Clinic, a genetic disease analysis service is provided by the NGS process known as PGT-M (Preimplantation Genetic Testing for Monogenic Syndrome), formerly known as PGD, to detect specific diseases that cause mutation or missing gene (Deletion) and to prevent the disease caused by a single gene (Single Gene Disorder) that will be transmitted to the offspring
Who will benefit from PGT-M?
- Families with a single gene disease history
- Families with children with single gene disease